Dr. Jennifer Dumaine Carrasco Assistant Professor jennifer.dumaine@westpoint.edu Biography Dr. Dumaine Carrasco is an Assistant Professor in the Chemistry and Life Science department and will be leading a team of cadet researchers studying the impact of bacteriophage therapeutics on the microbiome during AY25 in the Biodefense Protection and Technology Lab. Dr. Dumaine graduated summa cum laude with a Bachelor of Arts in Biology and Spanish from Hanover College in Hanover, IN, in 2013. She earned a M.S. in Biology from Western Kentucky University in 2015, where she studied the impact of sleep interruptions on the immune system under the guidance of Dr. Noah Ashley. She then went on to pursue a Ph.D. in Cellular and Molecular Biology at the University of Pennsylvania in Philadelphia, PA. At UPenn, she was a recipient of the T32 Training Fellowship for Parasitology and worked in the lab of Dr. Boris Striepen to identify the effector proteins used by the protozoan parasite Cryptosporidium parvum to modify the host cell during infection. Following completion of a Ph.D., she conducted a post-doctoral fellowship in the Molecular Pathogenesis and Immunology department at Texas A&M University in the lab of Dr. James Samuel working to identify and characterize immune modulating effector proteins of the gram-negative bacterium Coxiella burnetii. Publications & Presentations Peer-Reviewed PublicationsJennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Jodi A. Gullicksrud, Emma Hunter, Boris Striepen. “Identification of MEDLE2 as a host-targeted effector in Cryptosporidium parvum.” eLife, 2021, 10:e70451.Breanne E. Haskins, Jodi A. Gullicksrud, Bethan A. Wallbank, Jennifer E. Dumaine, Amandine Guérin, , Ian S. Cohn, Keenan M. O’Dea, Ryan D. Pardy, Maria I. Merolle, Lindsey A. Shallberg, Emma N. Hunter, Jessica H. Byerly, Eleanor J. Smith, Gracyn Y. Buenconsejo, Briana I. McLeod, David A. Christian, Boris Striepen, and Christopher A. Hunter. “Transgenic expression of a model antigen by Cryptosporidium demonstrates that secreted antigens and cDC1s are required to generate parasite-specific CD8+ T cell responses.” Immunity, Under review, 2023. Alexis R. Gibson, Adam Sateriale, Jennifer E. Dumaine, Julie B. Engiles, Ryan D. Pardy, Jodi A. Gullicksrud, Keenan M. O’Dea, John G. Doench, Daniel P. Beiting, Christopher A. Hunter, Boris Striepen. “A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.” PLOS Pathogens, 2022, 18(5): e1010003.Rodrigo P. Baptista, Yiran Li, Adam Sateriale, Mandy Sanders, Karen Brooks, Alan Tracey, Brendan Ansell, Aaron Jex, Garret Winston Cooper, Ethan Daniel Smith, Rui Xiao, Jennifer. E Dumaine, Matthew Berriman, Boris Striepen, James A. Cotton and Jessica C. Kissinger. “Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights.” Genome Research, 2022, 32(1):203-213.Jennifer E. Dumaine, Jayesh Tandel, Boris Striepen. (2020). “Cryptosporidium parvum.” Trends in Parasitology, 2020, 36(5) 485-486.Jennifer E. Dumaine and Noah T. Ashley “Acute sleep fragmentation does not alter pro-inflammatory cytokine expression in brain or peripheral tissues of leptin-deficient mice.” PeerJ, 2018, 6: e4423.Noah T. Ashley, David W. Sams, Audrey C. Brown, Jennifer E. Dumaine. “Novel environment influences the effect of paradoxical sleep deprivation upon brain and peripheral cytokine gene expression.” Neuroscience Letters, 2016, 615: 55-9.Jennifer E. Dumaine, Noah T. Ashley. “Sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration in a mouse model.” American Journal of Physiology, 2015, 308 (12) R1062-9. Abstracts & Peer-Reviewed Conference ProceedingsJennifer E. Dumaine, Samantha Butler, Makenna Chrane, Erin VanSchaik, James Samuel. “Functional characterization of Coxiella burnetii nuclear-targeted effectors during infection.” American Society of Rickettsiology National Meeting. Snowbird, UT. June 2023. (Poster)Jennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Jodi A. Gullicksrud, Emma Hunter, Boris Striepen. “Cryptosporidium parvum exports proteins into the cytoplasm of its epithelial host cell.” Molecular Parasitology Annual Meeting, Virtual Poster Presentation. September 2020. (Poster)Jennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Jodi A. Gullicksrud, Emma Hunter, Boris Striepen. “Cryptosporidium parvum exports proteins into the cytoplasm of its epithelial host cell.” International Giardia and Cryptosporidium Meeting. Rouen, France. June 2019. (Oral)Jennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Jodi A. Gullicksrud, Emma Hunter, Boris Striepen. “Cryptosporidium parvum exports proteins into the cytoplasm of its epithelial host cell.” Molecular Parasitology Annual Meeting. Woods Hole, MA. September 2019. (Poster)Jennifer E. Dumaine, Adam Sateriale, Amita Reddy, Boris Striepen. “Cryptosporidium parvum exports proteins into the cytoplasm of its epithelial host cell.” Molecular Parasitology Annual Meeting. Woods Hole, MA. September 2018. (Oral & Poster)Jennifer E. Dumaine, Adam Sateriale, Amita Reddy, Boris Striepen. “Cryptosporidium parvum exports proteins into the cytoplasm of its epithelial host cell.” ParaCon. State College, PA. June 2018. (Oral)Jennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Boris Striepen. “Investigation into exported protein candidates in Cryptosporidium parvum.” CTEGD Annual Symposium. Athens, GA. April 2017. (Poster)Jennifer E. Dumaine, David W. Sams, Audrey C., Noah T. Ashley. “Sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone.” Kentucky Academy of Science Annual Meeting, Lexington, KY. November 2014. (Poster)Jennifer E. Dumaine, David W. Sams, Audrey C., Noah T. Ashley. “Sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone.” Domin Graduate Research Conference. Columbus, GA. October 2014. (Poster)