LTC Lucas Fallot Photo

LTC Lucas Fallot

Assistant Director, Center for Molecular Science

lucas.fallot@westpoint.edu

Biography

Lieutenant Colonel Fallot is an Assistant Professor in the Department of Chemistry and Life Science and teaches Organic Chemistry I and II. He graduated from the United States Military Academy in 2004, earning a B.S. in chemistry and life science. He has served as a network engineer (FA26A) for most of his career, having served as a field artillery officer and a finance officer before his functional area accession in 2008. In addition to his teaching duties, LTC Fallot is the Assistant Director of the Center for Molecular Science, serving sub-roles as the Research Course Director and the Project's Day officer-in-charge.

Ongoing Research Projects

LTC Fallot is a medicinal chemist interested in developing small molecules targeting G protein-coupled receptors to treat disease. This work entails the design and synthesis of libraries of a small compound, characterizing their structure-activity relationships through in vitro binding and functional assays, determining their pharmacokinetic parameters, and testing their effectiveness using an applicable disease model. He utilizes a multi-disciplinary, team-of-teams approach to pre-clinical drug discovery.

Publications & Presentations

Publications and Presentations

Courtney L. Fisher, Lucas B. Fallot, Tina C. Wan, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell, Zhan-Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, and John A. Auchampach*, “Characterization of Dual Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαOA Isoprotein Activation” ACS Pharmacol. Transl. Sci. 5, 8, 625–641 (2022). DOI: https://doi.org/10.1021/acsptsci.2c00076

Michael J. B. Kelly, Lucas B. Fallot, Jeffrey L. Gustafson, and B. Mikael Bergdahl*, “Water Mediated Wittig Reactions of Aldehydes in the Teaching Laboratory: Using Sodium Bicarbonate for the in Situ Formation of Stabilized Ylides” J. Chem. Educ. 93, 1631–1636 (2016). DOI: https://pubs.acs.org/doi/10.1021/acs.jchemed.6b00206

Lucas B. Fallot, R. Rama Suresh, Courtney L. Fisher, Veronica Salmaso, Noy Kaufman, Zhan-Guo Gao, John A. Auchampach, Kenneth A. Jacobson*, “Structure-Activity Studies 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators” J. Med. Chem. 65, 22, 15238-15262 (2022). DOI: https://doi.org/10.1021/acs.jmedchem.2c01170

*Corresponding author

Abstracts & Peer-Reviewed Conference Proceedings

Courtney L. Fisher, Tina C. Wan, Lucas B. Fallot, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell, Zhan-Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, John A. Auchampach (2022) Characterization of Novel A3 Adenosine Receptor Allosteric Modulators. Experimental Biology Annual Meeting, Philadelphia, PA.

Kenneth A. Jacobson, Dilip K. Tosh, R. Rama Suresh, Veronica Salmaso, Lucas B. Fallot, and Zhan-Guo Gao (2021) Design and Biological Activity of A3 Adenosine Receptor Modulators. 2nd Advanced Chemistry World Congress, Berlin, Germany.

Lucas B. Fallot, Melinda Z. Kalainoff, and Eileen M. Kowalski (2017) Peeking Inside the “Black Box”: Making Learning Visible Using an Ethnographic Perspective. 253rd American Chemical Society National Meeting, San Francisco, CA.

Matt Greb, Melinda Z. Kalainoff, Eileen M. Kowalski, and Lucas B. Fallot (2016) Implementing Guided Inquiry in a Small Class/Large Enrollment General Chemistry Course: Initial Findings. 2016 Annual Chemistry Teaching Symposium and Education Exhibition. Cleveland, OH.

Melinda Z. Kalainoff, Eileen M. Kowalski, and Lucas B. Fallot (2016) Contrasting the Affordances of Interactive Lecture and POGIL Environments in General Chemistry: An Ethnographic Study. Biennial Conference in Chemical Education, Greeley, CO.