Dr. Jennifer Dumaine Carrasco, PhD Assistant Professor Chemistry & Life Science Center for Molecular Science jennifer.dumaine [at] westpoint.edu About Education Research & Publications Dr. Dumaine Carrasco is an assistant professor in the Chemistry and Life Science department and will be leading a team of cadet researchers studying the impact of bacteriophage therapeutics on the microbiome during AY25 in the Biodefense Protection and Technology Lab. Dr. Dumaine graduated summa cum laude with a Bachelor of Arts in biology and Spanish from Hanover College in Hanover, IN, in 2013. She earned a M.S. in biology from Western Kentucky University in 2015, where she studied the impact of sleep interruptions on the immune system under the guidance of Dr. Noah Ashley. She then went on to pursue a Ph.D. in cellular and molecular biology at the University of Pennsylvania in Philadelphia. At UPenn, she was a recipient of the T32 Training Fellowship for Parasitology and worked in the lab of Dr. Boris Striepen to identify the effector proteins used by the protozoan parasite Cryptosporidium parvum to modify the host cell during infection. Following completion of a Ph.D., she conducted a post-doctoral fellowship in the Molecular Pathogenesis and Immunology department at Texas A&M University in the lab of Dr. James Samuel to identify and characterize immune modulating effector proteins of the gram-negative bacterium Coxiella burnetii. Ph.D., Cellular and Molecular Biology - University of PennsylvaniaM.S., Biology - Western Kentucky UniversityB.A., Biology and Spanish - Hanover College Research Interests Host-pathogen interactions Current Research Dr. Dumaine’s research focuses upon understanding host-pathogen interactions in intracellular infections using mammalian cell culture and proteomics to uncover new therapeutic targets and diagnostics for infection. Selected Publications Jennifer E. Dumaine, Adam Sateriale, Alexis Gibson, Amita Reddy, Jodi A. Gullicksrud, Emma Hunter, Boris Striepen. “Identification of MEDLE2 as a host-targeted effector in Cryptosporidium parvum.” eLife, 2021, 10:e70451.Breanne E. Haskins, Jodi A. Gullicksrud, Bethan A. Wallbank, Jennifer E. Dumaine, Amandine Guérin, , Ian S. Cohn, Keenan M. O’Dea, Ryan D. Pardy, Maria I. Merolle, Lindsey A. Shallberg, Emma N. Hunter, Jessica H. Byerly, Eleanor J. Smith, Gracyn Y. Buenconsejo, Briana I. McLeod, David A. Christian, Boris Striepen, and Christopher A. Hunter. “Transgenic expression of a model antigen by Cryptosporidium demonstrates that secreted antigens and cDC1s are required to generate parasite-specific CD8+ T cell responses.” Immunity, Under review, 2023.Alexis R. Gibson, Adam Sateriale, Jennifer E. Dumaine, Julie B. Engiles, Ryan D. Pardy, Jodi A. Gullicksrud, Keenan M. O’Dea, John G. Doench, Daniel P. Beiting, Christopher A. Hunter, Boris Striepen. “A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.” PLOS Pathogens, 2022, 18(5): e1010003.Rodrigo P. Baptista, Yiran Li, Adam Sateriale, Mandy Sanders, Karen Brooks, Alan Tracey, Brendan Ansell, Aaron Jex, Garret Winston Cooper, Ethan Daniel Smith, Rui Xiao, Jennifer. E Dumaine, Matthew Berriman, Boris Striepen, James A. Cotton and Jessica C. Kissinger. “Long-read assembly and comparative evidence-based reanalysis of Cryptosporidium genome sequences reveal new biological insights.” Genome Research, 2022, 32(1):203-213.Jennifer E. Dumaine, Jayesh Tandel, Boris Striepen. (2020). “Cryptosporidium parvum.” Trends in Parasitology, 2020, 36(5) 485-486.Jennifer E. Dumaine and Noah T. Ashley “Acute sleep fragmentation does not alter pro-inflammatory cytokine expression in brain or peripheral tissues of leptin-deficient mice.” PeerJ, 2018, 6: e4423.Noah T. Ashley, David W. Sams, Audrey C. Brown, Jennifer E. Dumaine. “Novel environment influences the effect of paradoxical sleep deprivation upon brain and peripheral cytokine gene expression.” Neuroscience Letters, 2016, 615: 55-9.Jennifer E. Dumaine, Noah T. Ashley. “Sleep fragmentation induces tissue-specific changes in cytokine gene expression and increases serum corticosterone concentration in a mouse model.” American Journal of Physiology, 2015, 308 (12) R1062-9.