LTC Lucas Fallot, PhD Assistant Professor Deputy Director - Center for Molecular Science Chemistry & Life Science Center for Molecular Science lucas.fallot [at] westpoint.edu About Education Research & Publications Lieutenant Colonel Fallot is an Assistant Professor in the Department of Chemistry and Life Science and teaches Organic Chemistry I and II. He graduated from the United States Military Academy in 2004, earning a B.S. in chemistry and life science. He has served as a network engineer (FA26A) for most of his career, having served as a field artillery officer and a finance officer before his functional area accession in 2008. In addition to his teaching duties, LTC Fallot is the Assistant Director of the Center for Molecular Science, serving sub-roles as the Research Course Director and the Project's Day officer-in-charge. Ph.D. in Molecular and Cell Biology - Uniformed Service University of the Health Sciences/National Institutes of Health M.S. in Chemistry - San Diego State University B.S. in Chemisty and Life Science - United States Military Academy Current Research LTC Fallot is a medicinal chemist interested in developing small molecules targeting G protein-coupled receptors to treat disease. This work entails the design and synthesis of libraries of a small compound, characterizing their structure-activity relationships through in vitro binding and functional assays, determining their pharmacokinetic parameters, and testing their effectiveness using an applicable disease model. He utilizes a multi-disciplinary, team-of-teams approach to pre-clinical drug discovery. Selected Publications Courtney L. Fisher, Lucas B. Fallot, Tina C. Wan, Robert F. Keyes, R. Rama Suresh, Amy C. Rothwell, Zhan-Guo Gao, John D. McCorvy, Brian C. Smith, Kenneth A. Jacobson, and John A. Auchampach*, “Characterization of Dual Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαOA Isoprotein Activation” ACS Pharmacol. Transl. Sci. 5, 8, 625–641 (2022). DOI: https://doi.org/10.1021/acsptsci.2c00076Michael J. B. Kelly, Lucas B. Fallot, Jeffrey L. Gustafson, and B. Mikael Bergdahl*, “Water Mediated Wittig Reactions of Aldehydes in the Teaching Laboratory: Using Sodium Bicarbonate for the in Situ Formation of Stabilized Ylides” J. Chem. Educ. 93, 1631–1636 (2016). DOI: https://pubs.acs.org/doi/10.1021/acs.jchemed.6b00206Lucas B. Fallot, R. Rama Suresh, Courtney L. Fisher, Veronica Salmaso, Noy Kaufman, Zhan-Guo Gao, John A. Auchampach, Kenneth A. Jacobson*, “Structure-Activity Studies 1H-Imidazo[4,5-c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators” J. Med. Chem. 65, 22, 15238-15262 (2022). DOI: https://doi.org/10.1021/acs.jmedchem.2c01170*Corresponding author